In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
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چکیده
منابع مشابه
In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indi...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2015
ISSN: 1678-8060,0074-0276
DOI: 10.1590/0074-02760150007